Análisis del rendimiento físico en jugadores de hockey sobre césped sub 14 / Analysis of physical performance in u14 field hockey players / Análise do desempenho físico em jogadores de hóquei em campo sub-14

El objetivo del presente estudio fue determinar el rendimiento físico de jugadores sub 14, durante los partidos del Torneo Nacional de Asociaciones 2019, disputado en la Provincia de Córdoba, Argentina. Se monitorearon cinco encuentros (tres de fase de grupo; uno, semi final y uno, final). La muestra fue de 50 casos monitorizados por unidades GPS (PlayerTek Plus), divididos por posición: Defensores Centrales (n = 2), Defensores Laterales (n = 5), Volantes (n = 4) y Delanteros (n = 6). Las variables analizadas fueron divididas en dos, por un lado, las variables de volumen y, por otro, las de intensidad. Las primeras fueron: Distancia Total (m) 4718 ± 0,95; Distancia en Sprint (entre 16 a 19 km/h) (m) 484,67 ± 268,28; Cantidad de Sprints (>19 km/h) (rep) 17,70 ± 9,67; Aceleraciones >2 m/s2 (rep) 32,28 ± 13,39 y Desaceleraciones >-2 m/s2 (rep) 44,47 ± 17,08. En cambio, las variables de intensidad fueron: Metros por minuto (m) 101,18 ± 13,52; Distancia en Sprint por Minuto (m) 10,35 ± 5,96; Cantidad de Sprint por Minuto (rep) 0,37 ± 0,22. En conclusión, se consideró que analizar objetivamente, el rendimiento físico de los jóvenes jugadores es de vital importancia ya que podríamos establecer planes estratégicos para mejorar su performance, como también, bajar la incidencia lesiva.

The objective of this study was to determine the physical performance of U14 players, during the matches of the 2019 National Association Tournament, played in the Province of Córdoba, Argentina. 5 matches were monitored (3 group phase, 1 semi-final and 1 final). The sample consisted of 50 cases monitored by GPS units (PlayerTek Plus), divided by position: Central Defenders (n = 2), Side Defenders (n = 5), Midfielders (n = 4) and Forwards (n = 6). The analyzed variables were divided into 2: the volume variables and the intensity variables. The first ones were: Total Distance (m) 4718 ± 0.95; Sprint distance (between 16 to 19 km/h) (m) 484.67 ± 268.28; Number of Sprints (> 19 km/h) (rep) 17.70 ± 9.67; Accelerations> 2 m/s2 (rep) 32.28 ± 13.39 and Decelerations> -2 m/s2 (rep) 44.47 ± 17.08. Instead, the intensity variables were Meters per minute (m) 101.18 ± 13.52; Distance in Sprint per minute (m) 10.35 ± 5.96; and Amount of Sprint per minute (rep) 0.37 ± 0.22. In conclusion, it was considered that objectively analyzing the physical performance of young players is of vital importance, since we could establish strategic plans to improve their performance, as well as lower the incidence of injury.

O objetivo deste estudo foi determinar o desempenho físico de jogadores menores de 14 anos, durante as partidas do Torneio de Associações Nacionais 2019, disputadas na Província de Córdoba, Argentina. Foram monitorizados 5 jogos (3 fases de grupos, 1 semifinal e 1 final). A amostra foi composta por 50 casos monitorados por GPS (PlayerTek Plus), divididos por posição: Defensores Centrais (n=2), Defensores Laterais (n=5), Meio-campistas (n=4) e Atacantes (n=6). As variáveis analisadas foram divididas em 2, de um lado as variáveis de volume e, de outro, as variáveis de intensidade. As primeiras foram: Distância Total (m) 4718 ± 0,95; Distância em Sprint (entre 16 a 19 km/h) (m) 484,67 ± 268,28; Número de Sprints (>19 km/h) (rep) 17,70 ± 9,67; Aceleração >2 m/s2 (rep) 32,28 ± 13,39 e desacelerações >-2 m/s2 (rep) 44,47 ± 17,08. Em vez disso, as variáveis de intensidade foram: Metros por minuto (m) 101,18 ± 13,52; Distância em Sprint por Minuto (m) 10,35 ± 5,96; Quantidade de Sprint por Minuto (rep) 0,37 ± 0,22. Em conclusão, considerou-se que analisar objetivamente o desempenho físico de jovens jogadores é de vital importância, pois podemos estabelecer planos estratégicos para melhorar seu desempenho, bem como diminuir a incidência de lesões.

Predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma / 器官移植

Tumor recurrence is the main issue that affects the long-term survival of recipients after liver transplantation for hepatocellular carcinoma. Accurate preoperative evaluation and proper selection of transplant recipients are the key factors affecting the long-term prognosis of recipients undergoing liver transplantation for hepatocellular carcinoma. Neutrophil, lymphocyte, C-reactive protein, platelet and fibrinogen (FIB) are major biomarkers that indicate inflammatory response of the host. Multiple studies have found that these biomarkers may not only represent the inflammatory response, but also could be integrated to predict tumor recurrence and long-term survival rate of the recipients following liver transplantation for hepatocellular carcinoma. These biomarkers mainly consist of neutrophil-to-lymphocyte ratio (NLR), Glasgow prognostic score (GPS), FIB, platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI), etc. In this article, research progresses on predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma were reviewed.

Effects of the S1PR3 specific agonist peptide GPS-725.017 on acute lung injury in mice / 中华急诊医学杂志

Objective:To design a modified S1PR3 specific agonist, GPS-725.017, and investigate its protective effect on acute lung injury by promoting macrophage clearance of bacteria.Methods:A short peptide derived from the intracellular region of S1PR3 receptor was named GPS725.017, which was modified with norleucine (Nle) and myristicacid (myr) at its N terminus. Mice were divided into the sham operation group, solvent group and GPS-725.017 treatment group. The acute lung injury model was induced by endotracheal injection of E. coli (5×10 6 CFU), and the experimental group was treated with GPS-725.017 (10 mg/kg). The 48-h survival rate of mice was recorded. After 5 h of modeling, the bacterial load and inflammatory cytokines in peripheral blood and lung were detected, and Vps34 protein content in alveolar macrophages was determined by Western blot. After 12-h of modeling, lung tissues were collected for H&E staining and pathological scores. Results:Compared with the solvent group, the survival rate of mice in the GPS-725.017 treatment group was significantly improved ( P<0.01), the bacterial CFU in blood and alveolar lavage fluid was significantly lower than that in the solvent group ( P<0.001), and the levels of TNF-α and IL-1β in blood and alveolar lavage fluid were significantly lower than those in the solvent group ( P<0.001). Western blot showed that the expression level of Vps34 protein in alveolar macrophages was significantly higher than that in the solvent group ( P<0.01). Histopathology result showed that the pathological damage of lung in the treatment group was significantly less than that in the solvent group ( P<0.001). Conclusions:The modified synthetic S1PR3 specific agonist GPS-725.017 could specifically activate the S1PR3 receptor on the membrane of alveolar macrophages and up-regulate the expression level of intracellular Vps34 protein, which can promote the removal of bacteria in alveolar macrophages, significantly reduce the degree of lung injury and improve the survival rate in ALI mice.

Demandas físicas de jugadores profesionales costarricenses de fútbol: Influencia de la posición de juego y nivel competitivo / Physical Demands of Costa Rican Professional Soccer Players: Influence of the Playing Position and the Competitive Level

Resumen La monitorización de las demandas físicas durante partidos de fútbol con tecnologías GPS proporciona información valiosa que puede ser utilizada para potenciar el rendimiento deportivo. Por tanto, el objetivo de este estudio fue conocer las demandas físicas de jugadores profesionales costarricenses de fútbol, así como analizar la influencia de la posición de juego y el nivel competitivo durante partidos. Sesenta futbolistas masculinos, 50 de la primera división del fútbol costarricense y 10 de una selección nacional absoluta de CONCACAF (SAC), fueron monitoreados con un Sistema de Posicionamiento Global (GPS) para cuantificar variables cinemáticas como la distancia recorrida (m), total y a diferentes intensidades (Z 1-5), velocidad máxima (km/h), impactos totales (g), aceleraciones (m/s) y desaceleraciones (m/s). Las posiciones de juego se categorizaron en: defensas (Def), mediocampistas (Med) y delanteros (Del), y el nivel competitivo en: a) SAC, b) Equipos de nivel élite (ENE) y c) Equipos de nivel sub-élite (ENS). Los resultados reflejaron diferencias significativas respecto al nivel competitivo en la distancia recorrida a diferentes intensidades Z1 (SAC >ENS >ENE), Z2 (ENE >SAC >ENS) y Z4 (ENE >SAC >ENS), aceleraciones (SAC >ENE >ENS) y en desaceleraciones (SAC >ENS >ENE). Por posiciones de juego, las diferencias estuvieron en la distancia total (Med >Def >Del), en la distancia recorrida en Z2 (Med >Def >Del) y Z3 (Med >Def >Del), así como en impactos totales (Med >Def >Del). Se concluye que el nivel competitivo influye sobre las demandas físicas. SAC registró más aceleraciones y desaceleraciones y, ENE recorrió mayor distancia a esfuerzos moderados e intensos. Existen diferencias en las posiciones de juego, los mediocampistas recorrieron mayores distancias y registraron más impactos.

Abstract Monitoring physical demands during soccer matches with GPS technologies provides valuable information that can be used to enhance sports performance. Therefore, this study aimed to know Costa Rican professional soccer players' physical demands and analyze the influence of the playing position and the competitive level during matches. Sixty male soccer players, 50 from the first division of Costa Rican soccer and 10 from an absolute national CONCACAF (SAC) team were monitored with a Global Positioning System (GPS) to quantify kinematic variables such as distance traveled (m), total and different intensities (Z 1-5), maximum speed (km/h), total impacts (g), accelerations (m / s) and decelerations (m/s). The game positions were categorized into defenses (Def), midfielders (Mid) and forward (For), and the competitive level in a) SAC, b) Elite level teams (ENE), and c) Sub-elite level teams (ENS). The results reflected significant differences regarding the competitive level in the distance traveled at different intensities Z1 (SAC >ENS >ENE), Z2 (ENE >SAC >ENS) and Z4 (ENE >SAC >ENS), in accelerations (SAC >ENE >ENS), and in decelerations (SAC >ENS >ENE). By game positions, the differences were in the total distance (Mid >Def >For), in the distance traveled in Z2 (Mid >Def >For) and Z3 (Mid >Def >For), as well as in total impacts (Mid >Def >For). It is concluded that the competitive level influences the physical demands. SAC registered more accelerations and decelerations, and ENE traveled a greater distance with moderate and intense efforts. There were differences between playing positions; midfielder traveled longer distances and recorded more impacts.

Resumo O monitoramento das demandas físicas durante partidas de futebol com tecnologias GPS fornece informações valiosas que podem ser usadas para aprimorar o desempenho atlético. Portanto, o objetivo deste estudo foi conhecer as demandas físicas dos jogadores de futebol profissional da Costa Rica, bem como analisar a influência da posição de jogo e do nível competitivo durante os jogos. Sessenta jogadores de futebol masculino, 50 da primeira divisão do futebol costarriquenho e 10 da seleção nacional absoluta da CONCACAF (SAC), foram monitorados com um Sistema de Posicionamento Global (GPS) para quantificar variáveis cinemáticas como distância percorrida (m), total já diferentes intensidades (Z 1-5), velocidade máxima (km / h), impactos totais (g), acelerações (m / s) e desacelerações (m / s). As posições de jogo foram categorizadas em: defensores (Def), meio-campistas (Med) e atacantes (Del), e o nível competitivo em: a) SAC, b) Times de elite (ENE) e c) times de nível pré-elite (ENS). Os resultados refletiram diferenças significativas em relação ao nível competitivo na distância percorrida em diferentes intensidades Z1 (SAC> ENS> ENE), Z2 (ENE> SAC> ENS) e Z4 (ENE> SAC> ENS), acelerações (SAC> ENE> ENS) e em desacelerações (SAC> ENS> ENE). Por posições de jogo, as diferenças foram na distância total (Med> Def> Del), na distância percorrida em Z2 (Med> Def> Del) e Z3 (Med> Def> Del), bem como nos impactos totais (Med > Def> Del). Conclui-se que o nível competitivo influencia as demandas físicas. O SAC registrou mais acelerações e desacelerações, e a ENE percorreu uma distância maior com esforços moderados e intensos. Existem diferenças nas posições de jogo, os meio-campistas percorreram distâncias maiores e registraram mais impactos.

Prognostic value of inflammation-based prognostic scores in patients with colorectal cancer

Background: Anatomopathological staging is the primary method to determine the prognosis of patients with colorectal carcinoma (CRC). However, new tools have been developed that can complement it, such as the analysis of the elevation of systemic inflammatory markers. Objective: To evaluate the impact of the elevation of scores based on inflammatory markers (the neutrophil-to-lymphocyte ratio [NLR], the Glasgow Prognostic Score [GPS], and isolated C-reactive protein [CRP]) in the prognosis of patients diagnosed with CRC and submitted to potentially curative surgery in Hospital de Braga, Portugal, between January 1st, 2005, and December 31st, 2010. Methods: A retrospective analysis of the data of 426 patients was performed, with a collection of several clinico-pathological variables, as well as the levels of lymphocytes, neutrophils, albumin and CRP, in the pre- and postoperative periods, to apply the different scores to the sample. Results: From the analysis of the survival curves, we concluded that patients with increased NLR in the pre- and postoperative periods present a lower cancer-related survival than patients with normal NLR (preoperative period: 93.7 versus 122 months; p<0.001; postoperative period: 112 versus 131 months; p=0.002). Patients with increased NLR in the pre- and postoperative periods also had a lower disease-free survival (preoperative period: 88.0 versus 122 months; p<0.001; postoperative period: 111 versus 132 months; p=0.002). In addition, increased pre- and postoperative NLR was associatedwith a higher risk of death due to CRC (preoperatively: hazard ratio [HR]=2.25; p<0.001; postoperatively: HR=2.18; p=0.003). However, the multivariate analysis shows that only postoperative NLR (ajusted HR =2.66; p=0.002) does so independently of the remaining variables. Conclusion: Regarding the scores applied to the sample, the NLR was the one that most consistently related to the prognosis of the patients. However, it would be useful to develop a prospective study that could confirm this relationship. (AU)

A systematic review of load control in football using a Global Navigation Satellite System (GNSS)

Abstract Aim: This systematic review aimed to evaluate various Global Navigation Satellite Systems (GNSS) receivers, based on the frequency applied, the number of satellites available, and the dilution of precision (DOP) presented to measure football player load control. Method: The systematic review followed the PRISMA recommendations. Four hundred and eighty-five articles were selected from two online databases (Scopus and ISI Web of Science) over five years, with 21 studies selected for this review. In these studies, the GNSS frequency ranged from 5 to 18 Hz, with 10 Hz as the most commonly used frequency. Results: Of the 21 selected studies, 20 presented the ideal horizontal dilution of precision (HDOP), and the number of satellites available varied from 5 to 20. There was no consensus on defining speed, acceleration, or deceleration zones. Conclusion: There was no uniformity in data collected from the devices. Most GNSS receivers do not adopt the international system of units (SI).

Foraging behavior and at-sea distribution of White-Tailed Tropicbirds in tropical ocean / Comportamento de forrageio e distribuição no mar do Rabo-de-palha-de-bico-laranja em oceano tropical

Abstract We used miniaturized GPS loggers and site observations to access foraging patterns and nest behaviour of the White-tailed Tropicbird Phaethon lepturus (WTTB), an endangered species at its South Atlantic breeding colony. Dual foraging pattern was observed with alternation between long and short foraging trips. Birds responsible for nest attendance engaged in short foraging trips with mean distance from colony of 25 ± 17 km, total distance covered of 79 ± 65 km and mean duration of 4.02 ± 5.28 hours. Birds flew by dawn and returned before dusk while partners were at sea for long foraging trips that ranged from four to 11 days, with mean maximum distance from colony of 105 ± 47.48 km. Chicks were usually left alone for hours and chick predation by Land Crab Johngartia lagostroma, egg consumption by Goniopsis cruentata and intra-specific competition are suspected to be responsible for high chick mortality rates.

Resumo Utilizamos aparelhos de GPS miniaturizados e observações de campo para determinar padrões de forrageio e comportamento em ninho da espécie ameaçada Rabos-de-palha-de-bico-laranja Phaethon lepturus em sua colônia reprodutiva do Atlântico Sul. Padrão dual de forrageio foi observado, com alternância entre viagens longas e curtas. Aves responsáveis por cuidado parental efetuaram viagens curtas de forrageio com em média 25 ± 17 km de distância da colônia, distância total percorrida média de 79 ± 65 km e duração média de 4.02 ± 5.28 horas. As aves saíram da colônia entre o amanhecer e o entardecer, enquanto seus parceiros estavam em alto-mar em viagens longas de quatro a 11 dias de duração, com média de distância máxima da colônia de 105 ± 47.48 km. Filhotes foram constantemente deixados sozinhos por várias horas, e predação por Johngartia lagostroma, consumo de ovos por Goniopsis cruentata e competição intra-específica possivelmente foram responsáveis por sua morte.

Knowledge, attitude and practices of general practitioners about use of antiviral drugs in viral infections other than HIV

Background: Antiviral drugs for viral infections other than HIV are effective only for hepatitis, herpes and influenza. It has been observed that general practitioners (GPs) treat viral infections with antibiotics. The use of antibiotics in viral infections is not rational. Hence, authors conducted this study to assess the Knowledge, Attitude and Practices of General Practitioners (GPs) about treatment of viral infections other than HIV.Methods: It was a descriptive, observational, cross- sectional study among 100 GPs in Southern Pune. A pretested questionnaire was used to assess their knowledge, attitude and practices about treatment of viral infections other than HIV. Prior informed written consent was taken from the GPs who were grouped under MBBS, BHMS and BAMS categories according to their qualifications. Correct answers among these groups were analysed using chi-square test, Spearman’s coefficient test and ANOVA.Results: The percentages of correct answers in the groups were comparable.56% GPs have poor knowledge of Influenza treatment.30-36% do not treat Herpes genitalis and zoster with antiviral drugs. Authors found that 44%, 30% and 28% of total GPs don’t have proper knowledge, attitude and practice respectively about common viral infections other than HIV and antiviral drugs.Conclusions: GPs are significantly unaware about rational use of antiviral drugs. They have poor knowledge about management of influenza.

The Effectiveness Of A Navigation System For Ambulance Service In Kuala Lumpur, Malaysia

@#The response and transport intervals of an ambulance dispatch are affected by various factors. The present ambulance system relies on the driver’s experience, knowledge of local road map and estimations of directions. These may contribute to delays, misdirection and inefficient utilization of resources. The objectives of this study were to assess the effects of GPS navigation device on the response and transport time intervals of an ambulance service operating in urban setting. This was a three-month experimental study involving simulated ambulance dispatch based in a hospital. A total of 50 simulated cycles were constructed. Travel time, arrival time and distance were documented from each cycle. The median actual response time using map and GPS navigation device was 11.82 min and 10.47 min respectively. The median actual transport time using map and GPS navigation device was 11.00 min and 10.74 min respectively. The differences in response time and transport time between map and GPS navigation were not statistically significant (p= 0.215 and p=0.710). The application of GPS reduced the error value between estimated and actual response time by 8.73%. It also reduced the mean error value between estimated and actual transport time by 1.42%. The result shows that the GPS navigation device allowed for more accurate travel time estimation and its application in an urban setting such as Kuala Lumpur has the potential to reduce ambulance response time.

Review of survey method for human time-activity pattern and its application in the exposure assessment of air pollutants / 中华预防医学杂志

Time activity pattern refers to the time and behavior of people at different locations. The knowledge of time-activity pattern is essential for air pollution exposure assessment when direct personal exposure monitoring can't not be conducted, because air pollutant concentrations may vary significantly by location and activity. This review is focused on the survey method for human time-activity pattern and its application in the exposure assessment of air pollutants. After comparing the diary-reported trips and Global Positioning System (GPS) recording method, we believed that diary-reported trips were more reliable in describing comprehensive and detail records of the behavior and environmental circumstances while GPS-recorded trend to maintain sound information of time, location and transportations. Meanwhile, according to different subjects, the air pollution exposure model could be divided for population and individuals. There were great difference between two types of model in many areas, including the required information about time, activity and microenvironment.

The Effectiveness of a Navigation System for Ambulance Service in Kuala Lumpur, Malaysia

The response and transport intervals of an ambulance dispatch are affected by various factors. The present ambulance system relies on the driver’s experience, knowledge of local road map and estimations of directions. These may contribute to delays, misdirection and inefficient utilization of resources. The objectives of this study were to assess the effects of GPS navigation device on the response and transport time intervals of an ambulance service operating in urban setting. This was a three-month experimental study involving simulated ambulance dispatch based in a hospital. A total of 50 simulated cycles were constructed. Travel time, arrival time and distance were documented from each cycle. The median actual response time using map and GPS navigation device was 11.82 min and 10.47 min respectively. The median actual transport time using map and GPS navigation device was 11.00 min and 10.74 min respectively. The differences in response time and transport time between map and GPS navigation were not statistically significant (p= 0.215 and p=0.710). The application of GPS reduced the error value between estimated and actual response time by 8.73%. It also reduced the mean error value between estimated and actual transport time by 1.42%. The result shows that the GPS navigation device allowed for more accurate travel time estimation and its application in an urban setting such as Kuala Lumpur has the potential to reduce ambulance response time.

Concordancia entre las escalas clínicas y los índices derivados del laboratorio de análisis del movimiento en el estudio de la marcha en niños con insuficiencia motora de origen central (IMOC) / Concordance between clinical scales and indexes derived from gait analysis studies of in children with cerebral palsy

Introducción La parálisis cerebral infantil (PC) se clasifica en términos de función según varias escalas: unas son clínicas, como el GMFCS (Gross Motor Function Classification System), FMS (Functional Mobility Scale) y el cuestionario de evaluación funcional FAQ, (Gillette Functional Assessment Walking Scale), y otras, realizadas en el laboratorio de movimiento, como el GDI (Gait Deviation Index) y el GPS (Gait Profile Score). El objetivo del estudio fue establecer la concordancia entre las escalas clínicas y las escalas derivadas del laboratorio de análisis de movimiento. Metodología Se incluyó a 104 niños entre 5 y 16 años con diagnóstico de PC. Se realizó un estudio transversal y retrospectivo en que se analizaron los datos de 3 escalas clínicas de movilidad funcional y un análisis en 3D de la marcha, realizado en el laboratorio de análisis de movimiento con un equipo SMART-D/BTS y dos plataformas de fuerza. Resultados Respecto a la concordancia entre las escalas evaluadas, encontramos que el valor más alto de kappa (0,416) se obtuvo al confrontar FAQ y FMS a 50 m, lo que demostró una concordancia moderada. El resto de valores de kappa al comparar las diferentes escalas fueron menores a 0,4. Al relacionar las escalas según el porcentaje de acuerdo, encontramos que el mayor fue entre FMS y GPS con el 62,5%, seguido del 60,5% entre FAQ y FMS. Discusión No siempre una correlación aceptable significa una alta concordancia para clasificar a los pacientes en el mismo nivel de compromiso. La baja concordancia entre la mayoría de las escalas indica que el análisis de la marcha en el niño con PC debe realizarse de manera complementaria y llevar a cabo una evaluación con escalas clínicas, de calidad de vida, de funcionalidad y con el laboratorio de análisis de movimiento. Nivel de evidencia clínica. Nivel II.

Background Cerebral Palsy (CP) in children can be classified in terms of function according to several scales, some clinics such as GMFCS (Gross Motor Function Classification System), FMS (functional mobility Scale), FAQ (Gillette Functional Assessment Walking Scale); and others carried out in gait analysis such as the GDI (Gait Deviation Index), GPS (Gait Profile Score). The aim of this study was to determine the concordance between the clinical and gait analysis scales. Methods 104 children between five and sixteen years old diagnosed with Cerebral palsy were included. A cross sectional and retrospective study analyzed data from three clinical scales of functional mobility and a 3D gait analysis were carried out in gait analysis laboratory, using a SMART-D/BTS equipment and two strength platforms. Results Regarding the concordance between the scales evaluated, we found that the highest value of kappa (0416), occurred when confronting FAQ and FMS at 50 m, showing a moderate concordance. The remaining values of Kappa when comparing the different scales were smaller than 0.4. While when comparing the scales according to the percentage of agreement we found that the highest percentage was 62.50% when comparing FMS against GPS, followed by 60.50% when comparing FAQ against FMS. Discussion Not always an acceptable correlation means a high agreement to classify patients at the same level of involvement. The low correlation between most of the scales indicates that the gait analysis in children with Cerebral Palsy should be performed in a complementary manner, performing an assessment with clinical scales, quality of life, and functionality and with instrumented motion analysis. Evidence level. II.

Comparisons of recovery, external and internal load by playing position and match outcome in professional soccer

AIMS: To compare the internal and external load and the recovery by playing position and the match outcome (wins, losses or draws) in professional soccer. METHODS: 23 male professional soccer athletes from a team of the first division of the Brazilian Championship took part into the study (age 26.1 ± 3.8 years old, weight 77.5 ± 5.0 kg, height 177.6 ± 5.1 cm). During the games, athletes were monitored by GPS and the variables of external loads were taken. Additionally, the session rating of perceived exertion (session RPE) and the perceived recovery scale (PRS) were collected 30 minutes and 40h after the end of the matches, respectively. RESULTS: The external load was greater on full-backs and defense midfielders (p<0.05). The full-backs cover higher total distances compared to attackers, and, compared to all the others positions, they have more stimuli > 20 km/h, covering higher distances >20 km/h; these stimuli makes them to perceive less recovered than defenders, defense and attack midfielders (p<0.05). Moreover, the defenders are those who cover lower distances by the minute and the defense midfielders are those who present the lower Peak Velocity (p<0.05). There were no significant differences between GPS variables, internal load and recovery. In addition, it was found a correlation between the external and the internal load (r=0.66; p=0.001). CONCLUSIONS: The GPS variables and the perceived recovery are influenced by the playing position, but not by the match outcome.(AU)

Demands of two small-sided games of Costa Rican college soccer players

The purpose of this paper was to compare two small-sided games kinematics of Costa Rican college soccer players. Two SSG (2x10min, 3 min rest in between), C1 (600m2) and C2 (1200m2), were played by 14 college soccer players of Costa Rica. Global Positioning System was used to measure kinematic and physiological variables in both conditions. A mixed ANOVA was used, results suggested C1 and C2 were statistically different in speed (C1 C2). When analyzing the distance covered by speed category (low, moderate and high running actions) results suggest C2 had higher intensities compared to C1. This research confirms the findings of previousstudies on the effectiveness of SSG to simulate real game conditions in short periods of time. Conclusions: C2 had higher intensities compared to C1 game with lower physiological demand. Likewise, the C2 resembles more accurately matches in official conditions of Costa Rican players.

O propósito desta pesquisa foi comparar as demandas cinemáticas em dois tipos de dimensões de jogo em 14 jogadores costarricenses de futebol universitário. Estes jogaram dois jogos em campo reduzido (SSG) (2x10 min, 3 min de descanso): C1 (600m2) e C2 (1200 m2). Utilizou-se um Sistema de Posicionamento Global para medir as variáveis cinemáticas e fisiológicas em ambas as condições. Utilizou-se um ANOVA misto; os resultados sugeriram que C1 e C2 foram estatisticamente diferentes em velocidade (C1 C2). Ao analisar a distância percorrida pela categoria de velocidade, em ações de corrida baixa, moderada e alta intensidade, os resultados sugerem que C2 possui maiores intensidades em comparação a C1. Esta pesquisa confirma os resultados de estudos prévios sobre a efetividade de SSG para simular condições de jogo real em períodos curtos de tempo. Conclusões: O C2 apresentou uma maior intensidade em comparação ao jogo C1, com menores demandas fisiológicas. Igualmente, o C2 reflete de maneira mais exata as condições em jogos oficiais de jogadores costarricenses.

El propósito de esta investigación fue comparar las demandas cinemáticas en dos tipos de dimensiones de juego en jugadores de fútbol universitario costarricenses. 14 jugadores universitarios de fútbol de Costa Rica jugaron dos juegos en campo reducido (SSG) (2x10min, 3min de descanso): C1 (600m2) y C2 (1200 m2). Se utilizó un Sistema de Posicionamiento Global para medir las variables cinemáticas y fisiológicas en ambas condiciones. Se utilizó un ANOVA mixto; los resultados sugirieron que C1 y C2 fueron estadísticamente diferentes en velocidad (C1 C2). Al analizar la distancia recorrida por la categoría de velocidad; en acciones de carrera baja, moderada y alta intensidad, los resultados sugieren que C2 posee mayores intensidades en comparación con C1. Esta investigación confirma los resultados de estudios previos sobre la efectividad de SSG para simular condiciones de juego real en períodos cortos de tiempo. Conclusiones: El C2 presentó una mayor intensidad en comparación con el juego C1 con menores demandas fisiológicas. Asimismo, el C2 refleja de manera más exacta las condiciones en partidos oficiales de jugadores costarricenses.

Purifying process of gynostemma pentaphyllum saponins based on "adjoint marker" online control technology and identification of their compositions by UPLC-QTOF-MS / 中国中药杂志

To optimize the purification process of gynostemma pentaphyllum saponins (GPS) based on "adjoint marker" online control technology with GPS as the testing index. UPLC-QTOF-MS technology was used for qualitative analysis. "Adjoint marker" online control results showed that the end point of load sample was that the UV absorbance of effluent liquid was equal to half of that of load sample solution, and the absorbance was basically stable when the end point was stable. In UPLC-QTOF-MS qualitative analysis, 16 saponins were identified from GPS, including 13 known gynostemma saponins and 3 new saponins. This optimized method was proved to be simple, scientific, reasonable, easy for online determination, real-time record, and can be better applied to the mass production and automation of production. The results of qualitative analysis indicated that the "adjoint marker" online control technology can well retain main efficacy components of medicinal materials, and provide analysis tools for the process control and quality traceability.

Study of the activating effects of myristoyl-glycine modified peptide which derived from S1PR3 / 中华急诊医学杂志

Objective To study the effects of the myristoyl-glycine modified peptide which derived from the second intracellular loop of sphingosine 1-phosphate receptor 3 (S1PR3) on activation of mitogenactivated protein kinases (MAPKs) pathway.Methods The phosphorylation levels of JNK and ERK in THP-1 cells were detected by western blot after GPS-725.017 stimulation.Statistical data analysis was conducted by multivariate analysis of variance.Results Western blot showed that 10 min after 30 μmol/L or 50 μmol/L GPS-725.017 stimulated,phosphorylation of ERK significantly increased in comparison with the solvent-treated group [30 μmol/L group:(3.10 ± 0.27) vs.(7.98 ± 0.45),P ＜ 0.01;50 μmol/L group:(4.78 ±0.44) vs.(25.98 ±2.32),P ＜0.01];after 50 μmol/L GPS-725.017 stimulated THP-1 cells for 5 min,10 min,20 min or 30 min,p-ERK or p-JNK level raised at different time points (P ＜0.01vs.solvent group).Conclusions GPS-725.017,a kind of myristoyl-glycine modified peptide derived from S1 PR3,could traverse cytomembrane and activate MAPKs pathway.This study provides an implication of targeting S1PR3 for clinical therapy on inflammatory diseases or sepsis.

Foraging behavior and at-sea distribution of White-Tailed Tropicbirds in tropical ocean

Abstract We used miniaturized GPS loggers and site observations to access foraging patterns and nest behaviour of the White-tailed Tropicbird Phaethon lepturus (WTTB), an endangered species at its South Atlantic breeding colony. Dual foraging pattern was observed with alternation between long and short foraging trips. Birds responsible for nest attendance engaged in short foraging trips with mean distance from colony of 25 ± 17 km, total distance covered of 79 ± 65 km and mean duration of 4.02 ± 5.28 hours. Birds flew by dawn and returned before dusk while partners were at sea for long foraging trips that ranged from four to 11 days, with mean maximum distance from colony of 105 ± 47.48 km. Chicks were usually left alone for hours and chick predation by Land Crab Johngartia lagostroma, egg consumption by Goniopsis cruentata and intra-specific competition are suspected to be responsible for high chick mortality rates.

Resumo Utilizamos aparelhos de GPS miniaturizados e observações de campo para determinar padrões de forrageio e comportamento em ninho da espécie ameaçada Rabos-de-palha-de-bico-laranja Phaethon lepturus em sua colônia reprodutiva do Atlântico Sul. Padrão dual de forrageio foi observado, com alternância entre viagens longas e curtas. Aves responsáveis por cuidado parental efetuaram viagens curtas de forrageio com em média 25 ± 17 km de distância da colônia, distância total percorrida média de 79 ± 65 km e duração média de 4.02 ± 5.28 horas. As aves saíram da colônia entre o amanhecer e o entardecer, enquanto seus parceiros estavam em alto-mar em viagens longas de quatro a 11 dias de duração, com média de distância máxima da colônia de 105 ± 47.48 km. Filhotes foram constantemente deixados sozinhos por várias horas, e predação por Johngartia lagostroma, consumo de ovos por Goniopsis cruentata e competição intra-específica possivelmente foram responsáveis por sua morte.

Does Plan B work? Home range estimations from stored on board and transmitted data sets produced by GPS-telemetry in the Colombian Amazon / ¿Funciona el plan B? Estimación de rango de hogar a partir de datos almacenados en instrumentos a bordo de animales y los obtenidos a partir de telemetría satelital de GPS en el Amazonas colombiano

Abstract:Telemetry based on Global Positioning Systems (GPS) makes possible to gather large quantities of information in a very fine scale and work with species that were impossible to study in the past. When working with GPS telemetry, the option of storing data on board could be more desirable than the sole satellite transmitted data, due to the increase in the amount of locations available for analysis. Nonetheless, the uncertainty in the retrieving of the collar unit makes satellite-transmitted technologies something to take into account. Therefore, differences between store-on-board (SoB) and satellite-transmitted (IT) data sets need to be considered. Differences between SoB and IT data collected from two lowland tapirs (Tapirus terrestris), were explored by means of the calculation of home range areas by three different methods: the Minimum Convex Polygon (MCP), the Fixed Kernel Density Estimator (KDE) and the Brownian Bridges (BB). Results showed that SoB and IT data sets for the same individual were similar, with fix ranging from 63 % to 85 % respectively, and 16 m to 17 m horizontal errors. Depending on the total number of locations available for each individual, the home ranges estimated showed differences between 2.7 % and 79.3 %, for the 50 % probability contour and between 9.9 % and 61.8 % for the 95 % probability contour. These differences imply variations in the spatial coincidence of the estimated home ranges. We concluded that the use of IT data is not a good option for the estimation of home range areas if the collar settings have not been designed specifically for this use. Nonetheless, geographical representations of the IT based estimators could be of great help to identify areas of use, besides its assistance to locate the collar for its retrieval at the end of the field season and as a proximate backup when collars disappear. Rev. Biol. Trop. 64 (4): 1441-1450. Epub 2016 December 01.

Resumen:La telemetría basada en los sistemas de geopocisionamiento global (GPS) hace posible recopilar gran cantidad de información a escalas muy finas, y trabajar con especies imposibles de estudiar en el pasado. Al trabajar con telemetría de GPS, la opción de guardar información en la memoria interna del instrumento puede ser más deseable que sólo tener acceso a la información enviada vía satélite, debido a la mayor cantidad de localizaciones disponibles para analizar. No obstante, la incertidumbre de recuperar el collar hace que las tecnología de trasmisión vía satélite deba ser tenida en cuenta. Diferencias entre las bases de datos almacenadas en el collar (SoB) y las trasmitidas vía satélite (IT), recolectadas de dos individuos de Tapir de tierras bajas (Tapirus terrestris), son consideradas, en términos de las áreas de los rangos de hogar calculados con cada uno y mediante el uso de tres metodologías diferentes: Mínimo Polígono Convexo (MCP), Estimador de Densidad de Kernel Fijo (KDE) y los Puentes Brownianos (BB). Las bases de datos SoB e IT son similares, con tasas de acierto de localizaciones que oscilan entre 63 % to 85 % y errores horizontales de 16 m y 17 m respectivamente. Dependiendo del número total de localizaciones disponibles para cada individuo, los rangos de hogar estimados muestran diferencias entre 2.7 % y 79.3 %, para el contorno del 50 % de probabilidades, y entre 9.9 % y 61.8 % para el contorno del 95 % de probabilidades. Estas diferencias implican variaciones en la coincidencia espacial de los rangos de hogar estimados. Concluimos que el uso de la información trasmitida vía satélite no es una buena opción para la estimación de rangos de hogar, si la programción de los collares no ha sido diseñada específicamente para tal fin. Sin embargo, las representaciones geográficas de los estimados a partir de las bases de datos IT pueden ser de gran ayuda para la identificación de áreas de uso, además de su utilidad para la localización y recuperación de collares tras su liberación de los individuos monitoreados y como una base de datos de soporte en caso de pérdida del collar.

Tecnogeografias: modulações nas ecologias e políticas cognitivas / Technogeography: rearrangements in cognitive ecologies and politics

Resumo Apresentamos uma pesquisa-intervenção concebida para analisar o jogo de localização "Um dia no Jardim Botânico", projetado para ser jogado por crianças e adolescentes no Jardim Botânico de Porto Alegre. Usando o jogo como instrumento de pesquisa, investigamos as articulações e percepções que ele ofereceu aos jogadores durante a exploração do espaço híbrido Jardim-jogo. Consideramos o campo empírico da pesquisa como um espaço tecnogeográfico que se configura localmente e constitui planos de consistência para a existência de objetos e ações e suas relações que são, ao mesmo tempo, ficcionais e reais. Assim, seguimos os efeitos do jogo tomado como uma experiência programada que participa do modo como percepções e explorações ocorrem nesse espaço público; bem como as modulações nas políticas e ecologias cognitivas que daí emergem. As oficinas nos permitiram acompanhar o processo de reconfiguração da política cognitiva desse espaço e repensar o conceito de experiência programada nos jogos de localização.(AU)

Abstract This is an intervention research intended to analyze a gps-based game named "A day at the Botanical Garden", designed for children and teenagers at Porto Alegre´s Botanical Garden. By using the game as a research instrument, we meant to investigate the articulations of actions and perceptions it makes possible as players explore the hybrid garden-game space. Such empirical field is herein understood as a technogeographic space, locally arranged and able to offer patterns of consistency to the existence of objects and their relations, being simulteneaously real and fictional. We therefore consider the game as a designed experience that participates in the way perceptions and explorations emerge in a public space; as well as the cognitive ecologies and politics it might enable. By conducting a series of workshops with the game, we could track the rearrangements in players´ cognitive politics and rethink the concept of designed experienced applied to gps-based games.(AU)

Global positioning system & Google Earth in the investigation of an outbreak of cholera in a village of Bengaluru Urban district, Karnataka.

Background & objectives: The global positioning system (GPS) technology along with Google Earth is used to measure (spatial map) the accurate distribution of morbidity, mortality and planning of interventions in the community. We used this technology to find out its role in the investigation of a cholera outbreak, and also to identify the cause of the outbreak. Methods: This study was conducted in a village near Bengaluru, Karnataka in June 2013 during a cholera outbreak. House-to-house survey was done to identify acute watery diarrhoea cases. A hand held GPS receiver was used to record north and east coordinates of the households of cases and these values were subsequently plotted on Google Earth map. Water samples were collected from suspected sources for microbiological analysis. Results: A total of 27 cases of acute watery diarrhoea were reported. Fifty per cent of cases were in the age group of 14-44 yr and one death was reported. GPS technology and Google Earth described the accurate location of household of cases and spot map generated showed clustering of cases around the suspected water sources. The attack rate was 6.92 per cent and case fatality rate was 3.7 per cent. Water samples collected from suspected sources showed the presence of Vibrio cholera O1 Ogawa. Interpretation & conclusions: GPS technology and Google Earth were easy to use, helpful to accurately pinpoint the location of household of cases, construction of spot map and follow up of cases. Outbreak was found to be due to contamination of drinking water sources.